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organoids

University of Wisconsin Ophthalmology Professor Receives $75,000 Grant to Support International Collaborations on Eye Research

[Ophthalmology Times] Dr. Steven DeVries, a professor of Ophthalmology at the University of Wisconsin, has received an International Research Collaborators Award from Research to Prevent Blindnes that will allow him to learn from scientists at Ritsumeikan University in Japan about the process of growing 3D retinal organoids from stem cells.

Human Alveolar Type 2 Epithelium Transdifferentiates into Metaplastic KRT5+ Basal Cells

[Nature Cell Biology] Researchers demonstrated that human alveolar type 2 cells (hAEC2s), unlike murine AEC2s, transdifferentiated into basal cells in response to fibrotic signaling in the lung mesenchyme, in vitro and in vivo.

Intermittent Compressive Force Induces Cell Cycling and Reduces Apoptosis in Embryoid Bodies of Mouse Induced Pluripotent Stem Cells

[International Journal of Oral Science] Scientists identified a molecular mechanism in iPSCs responding to intermittent compressive force by analyzing the global gene expression profile.

Human iPSC-Derived Fallopian Tube Organoids with BRCA1 Mutation Recapitulate Early-Stage Carcinogenesis

[Cell Reports] Researchers generated human fallopian tube epithelial (FTE) organoids from BRCA1 mutation carriers that provided a faithful physiological in vitro model of FTE lesion generation and early carcinogenesis.

Development of a Personalized Intestinal Fibrosis Model Using Human Intestinal Organoids Derived From Induced Pluripotent Stem Cells

[Inflammatory Bowel Diseases] Induced pluripotent stem cells from two control individuals and two very early onset inflammatory bowel disease patients with structuring complications were obtained and directed to form human intestinal organoids.

Relevance of Biopsy-Derived Pancreatic Organoids in the Development of Efficient Transcriptomic Signatures to Predict Adjuvant Chemosensitivity in Pancreatic Cancer

[Translational Oncology] Investigators generated a prospective cohort of 27 consecutive biopsied derived pancreatic organoids and included them in the signature identification strategy.

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