organoids

[EMBO Journal] Scientists used cerebral organoids to identify key roles of neurotransmitter signaling pathways in guiding the migratory behavior of human cortical interneurons.

[Translational Psychiatry] Utilizing iPSCs from 25 human donors, researchers generated 3D cerebral organoids, employed 16-plex isobaric sample-barcoding chemistry, and simultaneously subjected samples to comprehensive high-throughput liquid-chromatography/mass-spectrometry quantitative proteomics.

[iScience] Investigators optimized the in vitro liver fibrotic niches and subsequently harvested their bioactive ingredients as niche extracts

[Molecular Metabolism] Human duodenal organoids were CRISPR-Cas9 modified to express the fluorescent protein Venus or the Ca2+ sensor GCaMP7s under control of the endogenous motilin promoter.

[Environmental and Molecular Mutagenesis] Focusing on human intestinal organoids, researcher highlight some of the key aspects that need to be considered and provide an outlook for future development in this exciting field.

[Experimental and Molecular Medicine] Scientists describe different gastrointestinal organoid methodologies and their applications for basic and translational cancer research.