organoids

[Nature] The authors outline the the Human Developmental Cell Atlas initiative and the challenges of mapping and modelling human development using state-of-the-art technologies to create a reference atlas across gestation.

[Genome Medicine] Whole-exome and total RNA sequencing was performed on 137 samples from 121 microsatellite stable colorectal cancers, including multiregional samples of primary and metastatic tumors from 4 patients.

[Molecular Psychiatry] The authors discuss how deficits in neurodevelopmental processes may lead to abnormal brain connectivity and how iPSC-based models can be used to identify abnormal connections and to gain insights into underlying cellular and molecular mechanisms to develop novel therapeutics.

[Cell Reports] Investigators showed that patient-derived glioma-stem cells recruited elevated levels of proteins that ensure the temporal cilium disassembly, leading to suppressed ciliogenesis.

[Cell Reports] Using DNA-label retaining, single-cell RNA sequencing, and other approaches, researchers investigated intestinal adenoma in response to chemoradiotherapy, thus identifying therapy-resistant tumor-initiating stem cells.

[Stem Cell Research & Therapy] Investigators developed precise culture conditions for gastric organoids in vitro to improve the accuracy of the generation of organoid models for therapeutic and medical applications.