organoids

[EMBO Molecular Medicine] Researchers generated an in vitro model for developmental and epileptic encephalopathies, using the devastating WW domain-containing oxidoreductase-related epileptic encephalopathy syndrome as a prototype, by establishing brain organoids from CRISPR-engineered human ES cells and from patient-derived induced pluripotent stem cells.

[American Journal of Physiology-Gastrointestinal and Liver Physiology] Direct exposure of colonic epithelial organoids to dextran sulfate sodium, oxazolone, or TNBS resulted in increased apoptosis and loss of Lgr5+ cells. Targeted ablation of Lgr5+ cells resulted in severe exacerbation of chronic, antibody-induced IL-10-deficient colitis, but had only modest effects in TNBS-induced colitis.

[Experimental Health Perspectives] The authors identified a potential synergy between mutation in the high-risk autism gene encoding chromodomain helicase DNA binding protein 8 and environmental exposure to an organophosphate pesticide an iPSC-derived human 3D brain model.

[Macromolecular Bioscience] Recently, synthetic polymeric hydrogels, with high biocompatibility and biodegradability, stability, uniformity of compositions, and high throughput properties, have emerged as potential materials for achieving 3D architectures for organoid cultures.

[International Journal of Cancer] The authors review the major developments in ovarian cancer, including genetics, model systems and technologies available for their study and the implications of applying epigenetic therapies to ovarian cancer.

[eLife] To overcome limitations and address species-specific cellular organization, investigators derived organoids from rapidly developing teleosts.