osteoblasts

[Nature Communications] Scientists described a de novo dominant neomorphic missense variant in SP7 in a patient with craniosynostosis, cranial hyperostosis, and long bone fragility. Histomorphometry showed increased osteoblasts but decreased bone mineralization.

[Cell Death & Differentiation] USP26 stabilized β-catenin to promote the osteogenic activity of MSCs and impaired the osteoclastic differentiation of bone myelomonocytes by stabilizing inhibitors of NF-κBα.

[Bone Research] Scientists evaluated growth differentiation factor-15 (GDF15) function using in vivo preclinical prostate cancer (PCa)-bone metastasis mouse models and an in vitro bone cell coculture system and suggested that PCa-secreted GDF15 promoted bone metastases and induced bone microarchitectural alterations in a preclinical xenograft model.

[Cancer Discovery] The authors leveraged genetic mouse models, patient-derived xenografts, and patient samples to show that acute myeloid leukemia exploited peripheral serotonin-signaling to remodel the endosteal niche to its advantage.

[Small] Investigators showed that high frequency MHz-order mechanostimulation in the form of nanoscale amplitude surface reflected bulk waves were capable of triggering differentiation of human MSCs from various donor sources toward an osteoblast lineage, with early, short time stimuli inducing long-term osteogenic commitment.

[Biofabrication] A bioinspired grid-crimp micropattern fabricated by melt electrospinning writing was proposed to mimic the native structure of bone-ligament interface.