osteoclasts

[Oncogene] Investigators observed that melatonin inhibited RANKL production in lung and prostate cancer cells by downregulating the p38 MAPK pathway, which in turn prevented cancer-associated osteoclast differentiation.

[Bone Research] The authors explore the current literature on adiponectin in bone, looking in depth at the comparison between human and murine data in health, with age and in disease.

[Theranostics] Researchers indicated that breast cancer cell-derived exosomes played an important role in promoting breast cancer bone metastasis, which was associated with the formation of pre-metastatic niche via transferring miR-21 to osteoclasts.

[Signal Transduction and Targeted Therapy] Researchers report that deleting Kindlin-2 in osteoblastic cells using the mouse 10-kb Dmp1-Cre largely neutralized the intermittent PTH-stimulated increasing of bone volume fraction and bone mineral density by impairing both osteoblast and osteoclast formation in murine adult bone.

[Nature] Investigators showed that the osteoclast differentiation receptor RANK couples female sex hormones to the rewiring of the thymus during pregnancy.

[Nature Communications] Investigators utilized single-nucleus RNA-sequencing to determine the extent of transcriptional diversity within multinucleated skeletal myofibers.