osteogenic differentiation

[npj Regenerative Medicine] Investigators presented evidence that during intramembranous bone formation osteoprogenitor cell proliferation is controlled by Notch signaling, while differentiation is initiated by activation of canonical Wnt signaling.

[Cell Death & Disease] Using conditional lineage-tracing mice, scientists demonstrated that chondrocytes gave rise to a sizable fraction of mesenchymal progenitor cells, which served as progenitors of chondrocyte-derived osteoblasts.

[Aging Cell] Alizarin red staining and quantification of calcium content showed that spermidine treatment markedly reduced mineral deposition in both rat and human vascular smooth muscle cells (VSMCs) under osteogenic conditions.

[Stem Cell Research & Therapy] Investigators evaluatedchondrogenic differentiation potential of menstrual blood-derived mesenchymal stem/stromal cells (MSCs) and bone marrow MSCs stimulated with transforming growth factor β (TGF-β3) and activin A.

[Cell Death Discovery] Investigators improve the understanding of the role of histone modifications in osteogenic differentiation and describe its potential as a therapeutic target for osteogenic differentiation-related diseases.

[Proceedings of the National Academy of Sciences of the United States of America] By single-cell transcriptional profiling of nonconditioned, matrix-conditioned, and early differentiating cells, researchers identified distinct MSC subpopulations with distinct mechanosensitivities, differentiation capacities, and cell cycling.