p53

[Scientific Reports] The authors characterized the anticancer activity of the A. testudineus antimicrobial peptides, which were synthetically produced and subjected to cytotoxic assay to prove their efficacy against cancer cell lines.

[Chemico-Biological interactions] Researchers investigated the role of components of the Hippo signaling pathway for E-cadherin-mediated contact inhibition of proliferation in the lungs after air pollution exposure.

[Cellular Immunology] Researchers examined tumor-infiltrating lymphocytes in colorectal cancer expressing different levels of SIRT1.

[Nature Communications] Researchers reported that bone marrow (BM) vascular endothelial cells secreted semaphorin 3 A (SEMA3A) in response to myeloablation and SEMA3A induced p53 – mediated apoptosis in BM endothelial cells via signaling through its receptor, Neuropilin 1 (NRP1), and activation of cyclin dependent kinase 5.

[Molecular Therapy-Methods & Clinical Development] Investigators found that the editing efficiency of cytosine base editor was significantly lower than that of adenine base editor in human ESCs, which were associated with high expression of DNA glycosylases, the key component of the base excision repair pathway.

[Journal of Clinical Investigation] Scientists showed that rescue of pyrimidine biosynthesis by administration of uridine or by genetic targeting of ENPP1/AMP pathway enhanced repair after cardiac injury.