p53

[Oncogene] The authors observed coordinate expression of IER2, p53/p21, and osteopontin in primary human melanomas and metastases, which highlighted the pathophysiological relevance of IER2-mediated senescence in melanoma progression.

[Cell Death & Disease] Investigators characterized a zebrafish smu471 mutant with hematopoietic stem/progenitor cell defects and found that sart3 was the causative gene.

[Molecular Therapy-Methods & Clinical Development] Researchers reported the first ever application of doggybone DNA (dbDNA™) vectors to generate human iPSCs. They achieved comparable iPSC reprogramming efficiencies using transiently expressing dbDNA™ vectors with the same iPSC reprogramming coding sequences as the state-of-the-art OriP/EBNA1 episomal vectors, in the absence of p53 shRNA repression.

[Cell Death Discovery] The authors review recent progress of ferroptosis studies delineating molecular mechanisms underlying the pathophysiology of several common liver diseases including ischemia/reperfusion-related injury, nonalcoholic fatty liver disease, alcoholic liver disease, hemochromatosis, drug-induced liver injury, and hepatocellular carcinoma.

[Scientific Reports] Researchers investigated the effects of p53 in primary sensitivity and acquired resistance to EGFR-TKIs in NSCLC cells.

[Pharmacological Research] The authors showed that the number of endothelial progenitor cells (EPCs) in hypertensive patients was significantly lower than that of normal population, and the cell function decreased with a higher proportion of EPCs at later stages.