p53

[Haematologica] By combining single cell analyses and P53 conformation-specific monoclonal antibodies scientists studied pre-leukemic-HSCs/progenitor cells from primary human DNMT3A-mutated AML samples.

[Journal of Agricultural and Food Chemistry] Cucurbitacin E (CE) belongs to the triterpenoids and has received substantial attention for its antineoplastic property. The authors revealed that CE significantly induced cellular senescence in colorectal cancer cells.

[Oncology Reports] In vitro, the AZD6738/5‑FU combination increased the number of mitotic cells according to flow cytometry, decreased the checkpoint kinase 1 phosphorylation levels and increased cleaved caspase‑3 and phosphorylated form of H2A.X variant histone levels according to western blotting, and decreased the proliferation rate of four colon cancer cell lines according to cell viability experiments.

[EMBO Journal] Using genome-wide CRISPR screening, the authors identified molecular factors that restricted heritable memory of epialleles in naïve PSCs, and demonstrated that removal of chromatin factor Dppa2 unlocked the potential for epigenetic inheritance uncoupled from DNA sequence.

[Molecular Therapy] Investigators screened LINC01234 as an aspartate metabolism-related lncRNA in HCC. Clinically, LINC01234 was highly expressed in HCC, and high LINC01234 expression level was correlated with poor prognosis of HCC patients.

[International Journal of Radiation Oncology Biology Physics] Researchers presented novel mechanistic evidence relating to signaling pathways with DNA damage responses in epidermal growth factor receptor-mutated glioblastoma multiforme.