p65

[Experimental Dermatology] In the skin, UV-irradiation increases expression of matrix metalloproteinases (MMPs) that causes dysregulation of extracellular matrix homeostasis in dermis, leading to acceleration of skin aging. Researchers reported the role of transglutaminase 2 in mediating the UVB-induced expression of MMP-1.

[Scientific Reports] Researchers showed that in mice and humans there was a spliced variant of p65, named p65 iso5, which bound the corticosteroid hormone dexamethasone amplifying the effect of the glucocorticoid receptor and was expressed in the liver of patients with hepatic cirrhosis and hepatocellular carcinoma.

[Animal] To investigate the preservative effects of vascular endothelial growth factor sensitization on ceramide-mediated programmed cell death of cardiomyocytes, palmitate-induced injury in H9c2 cells was established as an in vitro model.

[Scientific Reports] The authors revealed the important role of insulin gene enhancer-binding protein 1 (ISL1) in androgen receptor (AR)-dependent prostate cancer cell growth; ISL1 knockdown reduced the AR activity and cell growth.

[Cell Death & Disease] RNA sequencing was conducted to investigate the exosomal long non-coding RNA (lncRNA) transcriptome from myocardial infarction (MI) patients and identified 65 differentially expressed lncRNAs between the MI and control groups.

[Cell Death & Disease] Scientists evaluated the functional role of BRD9 in gastrointestinal stromal tumors (GIST) progression. Their findings demonstrated that the expression of BRD9 was upregulated in GIST tissues.