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pancreatic cancer cells

IMB5036 Inhibits Human Pancreatic Cancer Growth Primarily through Activating Necroptosis

[Basic & Clinical Pharmacology & Toxicology] MLKL inhibitor NSA attenuated the killing effect of IMB5036 on pancreatic cancer cells. IMB5036 stimulated translocation of MLKL and p-MLKL from cytoplasm to cell membrane.

Glycosylation of MUC6 by α1,4-Linked N-acetylglucosamine Enhances Suppression of Pancreatic Cancer Malignancy

[Cancer Science] Investigators ectopically expressed α1,4-N-acetylglucosaminyltransferase (α4GnT), the α1,4-linked N-acetylglucosamine biosynthetic enzyme, together with MUC6 in the human pancreatic cancer cell lines MIA PaCa-2 and PANC-1, neither of which expressed α4GnT and MUC6.

MCT4 as a Potential Therapeutic Target to Augment Gemcitabine Chemosensitivity in Resected Pancreatic Cancer

[Cellular Oncology] Investigators identified the prognostic significance and therapeutic options of metabolic subtypes of resectable pancreatic cancer.

HIG1 Domain Family Member 1A Disrupts Proliferation, Migration and Invasion of Colon Adenocarcinoma Cells

[Bioengineered] Higd-1a promotes the proliferation of pancreatic cancer cells and the growth of pancreatic cancer; however, no similar observations have been reported for colorectal cancer (CRC). This study, researchers verified the role of Higd-1a in colorectal cancer.

MicroRNA-190b Expression Predicts a Good Prognosis and Attenuates the Malignant Progression of Pancreatic Cancer by Targeting MEF2C and TCF4

[Oncology Reports] Scientists examined the expression of miR‑190b in pancreatic cancer cell lines and tissues and evaluated its effects on cancer progression.

ACY-241, an HDAC6 Inhibitor, Overcomes Erlotinib Resistance in Human Pancreatic Cancer Cells by Inducing Autophagy

[Archives of Pharmacal Research] Researchers evaluated the anticancer effect of ACY-241, an HDAC6-selective inhibitor, on erlotinib-resistant pancreatic cancer cells that overexpressed HDAC6.

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