pancreatic cells

[Biochemical Pharmacology] Scientists discuss the implications of a heterogenous insulin secretory granules (ISG) population in β-cells and highlight the need for more understanding into how unique ISG populations may be targeted in anti-diabetic therapies.

[Journal of Diabetes Research] Scientists review recent study updates of sphingosine 1 phosphate (S1P), summarizing its effects on type 2 diabetes mellitus with respect to pathogenesis, promoting β cell proliferation and inhibiting apoptosis, reducing insulin resistance, protecting the liver and pancreas from lipotoxic damage, improving intestinal incretin effects, lowering basal glucagon levels, etc.

[Circulation Journal] Researchers suggest that careful assessment of the status of converted cells using genetic and epigenetic profiling, various functional assays, and the use of multiple readouts is essential to determine successful conversion.

[Cancer Cell] Investigators showed that tumor-specific CD8+ tumor-infiltrating lymphocytes accumulated in tumor islets, where they engage antigen and upregulate PD-1, which restrained their functions.

[PLoS One] A new “endocrine pancreas” delivered islet hormones physiologically into the hepatic portal vein. Treatment of insulin-dependent dogs with allogeneic canine Neo-Islets consistently improved glycemic control without the need for antirejection drugs.

[Cell Reports] Investigators analyzed over two million cells from 16 pancreata obtained from donors with type 2 diabetes and 13 pancreata from age-similar non-diabetic controls.