pancreatic ductal adenocarcinoma

[Molecular & Cellular Proteomics] Researchers observed both common and distinct patterns of glycosylation in pancreatic cancer across species. Common alterations included increased levels of α-2,3- and α-2,6-sialic acids, bisecting GlcNAc and poly-LacNAc.

[Nature Communications] Researchers derived pancreatic ductal adenocarcinoma organoids from 18 primary tumors and two matched liver metastases, and showed that ‘classical’ and ‘basal-like’ cells coexist in individual organoids.

[Science Advances] Scientists visualized transient manipulation of focal adhesion kinase, which integrated bidirectional cell-environment signaling, using intravital fluorescence lifetime imaging microscopy of the FAK-based Förster resonance energy transfer biosensor in mouse and patient-derived pancreatic ductal adenocarcinoma models.

[Molecular Medicine Reports] RO 48‑8071 (RO) was used to treat the pancreatic cancer cell line in vitro to examine the effects of RO on cell viability, as well as to determine its potential molecular mechanism.

[Nature Communications] Researchers developed a comprehensive and highly tuneable ex vivo model of pancreatic ductal adenocarcinoma based on the 3D co-assembly of peptide amphiphiles with custom ECM components.

[American Journal of Human Genetics] Scientists proposed that intracellular accumulation of a nonfunctional chymotrypsinogen B2 protein led to endoplasmic reticulum stress and pancreatic inflammation, which might explain the increased pancreatic cancer risk in carriers of CTRB2 exon 6 deletion alleles.