A 584 BP Deletion in CTRB2 Inhibits Chymotrypsin B2 Activity and Secretion and Confers Risk of Pancreatic Cancer

Scientists proposed that intracellular accumulation of a nonfunctional chymotrypsinogen B2 protein led to endoplasmic reticulum stress and pancreatic inflammation, which might explain the increased pancreatic cancer risk in carriers of CTRB2 exon 6 deletion alleles.