pancreatitis

[Cell Death & Disease] The pancreas was analyzed by histology, immunochemistry staining, and TUNEL assays, and the expression of certain proteins and RNAs, cytokine levels, trypsin activity, and reactive oxygen species (ROS) levels were determined.

[Stem Cell Research & Therapy] The survival and colonization of exogenous placental chorionic plate-derived MSCs were observed by bioluminescence imaging and CM-Dil labeling in rodent animal models of severe acute pancreatitis.

[Cell Death & Disease] Researchers found that Ripk3−/− mice had significantly more severe pancreatic edema and inflammation associated with macrophage and neutrophil infiltration than control mice.

[Scientific Reports] Scientists provide a new cellular narrative for pancreatic development, homeostasis and response to injury via a small SETD4+ cell population.

[Aimmune Therapeutics, Inc.] Aimmune Therapeutics, a Nestlé Health Science company developing pharmaceutical therapies to prevent, manage and treat food and metabolic-related diseases, including exocrine pancreatic insufficiency (EPI), announced the launch of PACT-CP, a Patient-Centric Chronic Pancreatitis Registry study to better understand the unmet needs and therapeutic burden on patients with EPI due to chronic pancreatitis (CP).

[Cancer Research] Scientists re-analyzed multiple pancreas and pancreatic ductal adenocarcinoma single-cell RNA-seq datasets and found a subset of non-malignant acinar cells, which they refered to as acinar edge (AE) cells, whose transcriptomes highly diverged from a typical acinar cell in each dataset.