prostate cancer

[Nature Communications] Scientists generated a comprehensive prostate cancer transcriptome atlas that described the roadmap to tumor progression in a qualitative and quantitative manner. Using patient-derived xenograft models, they functionally validated their observations and add single-cell resolution.

[Oncogene] Investigators showed that endothelial-to-osteoblast (EC-to-OSB) transition led to changes in the tumor microenvironment that increased the metastatic potential of prostate cancer (PCa) cells. They found that conditioned medium from EC-OSB hybrid cells increased the migration and survival of PC3-mm2 and C4-2B4 PCa cells.

[Molecular Therapy-Nucleic Acids] The effect of PTEN on prostate cancer (PCa) cell migration, apoptosis and the cell cycle was analyzed in vitro using a wound healing assay and flow cytometry. The authors assessed the ability of intraprostatic and intratumoral injection of recombinant adeno-associated virus (rAAV) 9 expressing Pten or Cdkn1b to inhibit PCa progression.

[Cancer Cell International] Researchers noted that heterogeneous nuclear ribonucleoprotein K (HnRNPK) emerged as an important player in the carcinogenesis process of prostate cancer (PrCa). miR-206 and miR-613 suppressed HnRNPK expression by targeting its 3’-UTR in PrCa cell lines in which HnRNPK was overexpressed.

[Clinical and Translational Oncology] Scientists investigated the involvement of the SDF-1/CXCR4 axis in the process of bone marrow mesenchymal stem cells (BMMSC) homing in prostate cancer (PCa) in vivo and in vitro and suggested that BMMSCs could home and promote the proliferation and migration of PCa through the SDF-1/CXCR4 axis.

[Bioengineered] Investigators showed that hsa_circ_0030586 was significantly upregulated in prostate cancer (PCa) cells. Interfering with hsa_circ_0030586 in PC3 cells inhibited cell proliferation, migration, and invasion.