rAAV-Delivered PTEN Therapeutics for Prostate Cancer

The effect of PTEN on prostate cancer (PCa) cell migration, apoptosis and the cell cycle was analyzed in vitro using a wound healing assay and flow cytometry. The authors assessed the ability of intraprostatic and intratumoral injection of recombinant adeno-associated virus (rAAV) 9 expressing Pten or Cdkn1b to inhibit PCa progression.