prostate cancer

[Cancer Research] In a syngeneic model that reflected the mutational landscape of castrate-resistant prostate cancer, macrophage depletion resulted in a reduced transcriptional signature for steroid and bile acid synthesis, indicating potential perturbation of cholesterol metabolism.

[Biochemical and Biophysical Research Communications] The relevance of pleckstrin homology-like domain family A, member 3 (PHLDA3) in prostate cancer has not been explored. Scientists illustrated the possible roles and mechanisms of PHLDA3 in prostate cancer.

[Toxicology Letters] Since inorganic arsenic targets prostatic stem cells, researchers hypothesized that arsenic-transformed stem cells show an impaired TLR3-associated anti-tumor pathway and, therefore, are unresponsive to polyinosinic:polycytidylic acid activation.

[Prostate] Scientists proposed that alterations in DNA damage response pathway contributed to taxane resistance, and identification of these alterations may provide a potential therapeutic target to resensitize docetaxel-refractory mCRPC to taxane-based therapy.

[Journal of Cellular and Molecular Medicine] Investigators determined effects of LOC100996425 on human prostate cancer by targeting hepatocyte nuclear factor 4A via the AMPK/mTOR pathway.

[Scientific Reports] Investigators developed a sandwich ELISA to detect prostate-specific membrane antigen on small extracellular vesicles (EVs) using T-cell immunoglobulin domain and mucin domain-containing protein 4 as a capture molecule for EVs and to evaluate its diagnostic potential in urologic malignancies.