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protein expression

NLRP3 Inflammasome Activation in Human Peripheral Blood Mononuclear Cells Induced by Venoms Secreted PLAM2s

[International Journal of Biological Macromolecules] Peripheral blood mononuclear cells were isolated by density gradient and incubated with RPMI, LPS, BthTX-I or BthTX-II isolated from Bothrops jararacussu venom, to evaluate viability, and the results showed that there was no cell death.

A Large Scale Mass Spectrometry-Based Histone Screening for Assessing Epigenetic Developmental Toxicity

[Scientific Reports] Scientists developed a mass spectrometry-based proof-of-concept to assess a histone code screening assay capable of simultaneously detecting multiple hPTM-changes in human ESCs.

Galectin-1 Confers Resistance to Doxorubicin in Hepatocellular Carcinoma Cells through Modulation of P-glycoprotein Expression

[Cell Death & Disease] Researchers investigated the molecular mechanism underlying galectin-1-mediated chemoresistance in hepatocellular carcinoma cells, particularly the involvement of P-glycoprotein in this effect.

LncRNA ROR Modulates Myocardial Ischemia-Reperfusion Injury Mediated by the miR-185-5p/CDK6 Axis

[Laboratory Investigation] Researchers revealed that hypoxia/reoxygenation (H/R) treated human cardiac myocytes showed a significantly decreased miR-185-5p expression and increased expression of CDK6 and ROR.

Downregulated Calcium-Binding Protein S100A16 and HSP27 in Placenta-Derived Multipotent Cells Induce Functional Astrocyte Differentiation

[Stem Cell Reviews and Reports] The authors cross-compared transcriptomic and proteomic data and selected 26 candidate genes with the same expression trends in both omics analyses.

Stage-Specific Differential Expression of Zinc Transporter SLC30A and SLC39A Family Proteins during Prostate Tumorigenesis

[Molecular Carcinogenesis] Investigators assessed the stage-specific expression of zinc transporters (ZNTs) belonging to the ZNT (SLC30A) and Zrt- and Irt-like protein (SLC39A) solute-carrier family in the prostate tissues of different genetically engineered mouse models of prostate cancer, their age-matched wild-type controls, and 104 prostate core biopsies from human patients with different pathological lesions.

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