Effect of Duty Cycles of Tumor-Treating Fields on Glioblastoma Cells and Normal Brain Organoids

The authors evaluated the effects of tumor‑treating fields with different duty cycles on glioma spheroid cells and normal brain organoids.
[International Journal of Oncology]
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Robust Genome Editing in Adult Vascular Endothelium by Nanoparticle Delivery of CRISPR-Cas9 Plasmid DNA

A single intravenous administration of mixture of nanoparticles and plasmid DNA expressing Cas9 controlled by CDH5 promoter and guide RNA induced highly efficient genome editing in endothelial cells of the vasculatures, including lung, heart, aorta, and peripheral vessels in adult mice.
[Cell Reports]
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Functional Assessment of miR-1291 in Colon Cancer Cells

The expression and effect of miR‑1291 in colorectal cancer cells (CRC) was investigated. It was identified that miR‑1291 significantly suppressed the proliferation, invasion, cell mobility and colony formation of CRC cells.
[International Journal of Oncology]
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Ginkgo biloba Extract Inhibited Cell Proliferation and Invasion by Stimulating TET2 Expression through miR-29a in Colorectal Carcinoma Cells

Scientists analyzed the effects of Ginkgo biloba extract (GBE) administration on TET2 expression in human colorectal cancer (CRC). To investigate the expression profiles of TET2, GBE was used to treat CRC cells.
[DNA and Cell Biology]
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Identification of Gm15441, a Txnip Antisense lncRNA, as a Critical Regulator in Liver Metabolic Homeostasis

Scientists investigated the role of Gm15441 in the regulation of thioredoxin-interacting protein (Txnip) and liver metabolism and found that the expression levels of Gm15441 and Txnip showed a similar response pattern to metabolic signals in vivo and in vitro, but that their functions were predicted to be opposite.
[Cell & Bioscience]
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TCF4 and HuR Mediated-METTL14 Suppresses Dissemination of Colorectal Cancer via N6-Methyladenosine-Dependent Silencing of ARRDC4

Researchers reported that METTL14, a key component of N6-methyladenosine methylation, was functionally related to the inhibition of ARRDC4/ZEB1 signaling and to the consequent suppression of colorectal cancer metastasis.
[Cell Death & Disease]
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The Role of AKR1 Family in Tamoxifen Resistant Invasive Lobular Breast Cancer Based on Data Mining

Scientists explored the role of aldo-keto reductase family 1 (AKR1) family in tamoxifen-resistant aggressive lobular breast cancer based on data mining.
[BMC Cancer]
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The BH3-Only Protein Noxa Serves as an Independent Predictor of Breast Cancer Patient Survival and Defines Susceptibility to Microtubule Targeting Agents

The authors identified high NOXA/PMAIP mRNA expression levels as an independent prognostic marker for improved relapse-free survival and overall survival in multivariate analysis in breast cancer patients, independent of their molecular subtype.
[Cell Death & Disease]
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WNT11/ROR2 Signaling Is Associated with Tumor Invasion and Poor Survival in Breast Cancer

Scientists modulated the expression of ROR2 in human breast cancer cells and characterized their gene and protein expression by RNA-Seq, qRT-PCR, immunoblots and reverse phase protein array combined with network analyses to understand the molecular basis of ROR2 signaling in breast cancer.
[Journal of Experimental & Clinical Cancer Research]
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Cx43 Overexpression Is Involved in the Hyper-Proliferation Effect of Trichloroethylene on Human Embryonic Stem Cells

Scientists explored the toxic effects and mechanisms of trichloroethylene (TCE) on hESC proliferation. TCE exposure resulted in upregulation of Cx43 via Akt phosphorylation, consequently stimulated CDK2 expression, contributing to hyper-proliferation in hESCs.
[Toxicology]
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SOX10 Requirement for Melanoma Tumor Growth Is Due, in Part, to Immune-Mediated Effects

Researchers investigated immune-related targets of SOX10 and observed positive regulation of herpesvirus entry mediator and carcinoembryonic-antigen cell-adhesion molecule 1.
[Cell Reports]
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