publication

Investigators examined the consequences of polystyrene microplastics (PS-MPs) on the differentiation of hiPSCs into kidney organoids. Different concentrations of PS-MPs were set according to the concentration of PS-MPs detected in blood...

Researchers differentiated human embryonic stem cells into induced skeletal muscle (iMusc) cells to identify hypertrophic factors and generates a novel 3D human iMusc organoid model for studying the direct effects of...

Researchers reconstructed a human trophoblast organoid model, incorporating a near-physiological proportion of extravillous trophoblast. [Environmental Science & Technology] AbstractGraphical Abstract

Scientists established a methodology to generate right ventricle-like human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) to support the development of disease modeling research using chamber-specific hPSC-CMs. [Stem Cell Research & Therapy] Full Article

[Proceedings of the National Academy of Sciences of the United States of America] To identify tumor-intrinsic regulators of immunotherapy resistance and explore therapeutic strategies to restore T cell–mediated tumor control, scientists employed three functional genomics approaches using in vitro and in vivo CRISPR screening.

[Cancer Research] Scientists developed a therapeutic approach integrating circulating tumor DNA dynamics with sequential organoid drug screening to optimize breast cancer treatment. Analysis of 40 breast cancer organoid models demonstrated the potential of organoid culture supernatants for comprehensive mutation profiling and drug sensitivity testing.