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pulmonary cells

A cGAS-Dependent Response Links DNA Damage and Senescence in Alveolar Epithelial Cells: A Potential Drug Target in IPF

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Scientists investigated the role of the DNA-sensing GMP-AMP synthase in idiopathic pulmonary fibrosis, with a focus on alveolar epithelial cell senescence.

Escherichia coli Infection Activates the Production of IFN-α and IFN-β via the JAK1/STAT1/2 Signaling Pathway in Lung Cells

[Amino Acids] Researchers studied whether E. coli infections could regulate interferon production and the underlying mechanisms. Two lung cell lines, a human bronchial epithelial cell line transformed with Ad12-SV40 2B and a human fetal lung fibroblast cell line, were used.

The Petroleum Ether Extract of Brassica rapa L. Induces Apoptosis of Lung Adenocarcinoma Cells via the Mitochondria-Dependent Pathway

[Food & Function] The effects and pharmacological mechanisms of BRPS on the treatment of lung cancer were investigated both in vitro and in vivo.

Concomitant and Decoupled Effects of Cigarette Smoke and SCAL1 Upregulation on Oncogenic Phenotypes and ROS Detoxification in Lung Adenocarcinoma Cells

[Scientific Reports] A novel long noncoding RNA called smoke and cancer-associated lncRNA 1 was recently found upregulated in smoke-exposed adenocarcinomic alveolar epithelial cells.

Down-Regulation of lncRNA MEG3 Promotes Chronic Low Dose Cadmium Exposure-Induced Cell Transformation and Cancer Stem Cell-Like Property

[Toxicology and Applied Pharmacology] The long non-coding RNA microarray analysis showed that the expression level of a tumor suppressive lncRNA maternally expressed 3 was significantly down-regulated in cadium-transformed cells, which was confirmed by further q-PCR analysis.

Serum-Derived Exosomes from House Dust Mite-Sensitized Guinea Pigs Contribute to Inflammation in BEAS-2B Cells via the TLR4-NF-κB Pathway

[Molecular Medicine Reports] The authors investigated whether serum exosomes played a pro‑inflammatory role in bronchial epithelial cells and explored the underlying molecular mechanisms.

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