pulmonary cells

[Science Immunology] To identify potent antiviral innate immune agonists, researchers screened a panel of 75 microbial ligands that activate diverse signaling pathways and identified cyclic dinucleotides, canonical STING agonists, as antiviral.

[Nature Communications] Researchers showed that MEK inhibition enhanced PD-L1 expression while PD-L1 blockade upregulated MAPK signaling in mutant KRAS lung tumors.

[Cell Death & Disease] we found that YTHDF2 was significantly upregulated in Lung adenocarcinoma (LUAD) compared with paracancerous normal tissues, and YTHDF2 knockdown drastically inhibited, while its overexpression promoted, cell growth, colony formation and migration of LUAD cells in vitro.

[Clinical Infectious Diseases] Scientists measured the susceptibility to infection, immune response, and expression of adhesion molecules, in human pulmonary microvascular endothelial cells exposed to conditioned medium from infected epithelial cells.

[Laboratory Investigation] Researchers investigated the molecular mechanism of enhancer of zeste homolog 2 (EZH2) in the development of asthma.

[Proceedings of the National Academy of Sciences of the United States of America]