Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell Newswe found that YTHDF2 was significantly upregulated in Lung adenocarcinoma (LUAD) compared with paracancerous normal tissues, and YTHDF2 knockdown drastically inhibited, while its overexpression promoted, cell growth, colony formation and migration of LUAD cells in vitro.
[Cell Death & Disease]
7753456 SJCWZSX9 items 1 apa 0 default asc 1 162210 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-1be195555d714d5ccfca31b0ca1f6838%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22SJCWZSX9%22%2C%22library%22%3A%7B%22id%22%3A7753456%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Li%20et%20al.%22%2C%22parsedDate%22%3A%222021-05-13%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ELi%2C%20Y.%2C%20Sheng%2C%20H.%2C%20Ma%2C%20F.%2C%20Wu%2C%20Q.%2C%20Huang%2C%20J.%2C%20Chen%2C%20Q.%2C%20Sheng%2C%20L.%2C%20Zhu%2C%20X.%2C%20Zhu%2C%20X.%2C%20%26amp%3B%20Xu%2C%20M.%20%282021%29.%20RNA%20m%206%20A%20reader%20YTHDF2%20facilitates%20lung%20adenocarcinoma%20cell%20proliferation%20and%20metastasis%20by%20targeting%20the%20AXIN1%5C%2FWnt%5C%2F%26%23x3B2%3B-catenin%20signaling.%20%3Ci%3ECell%20Death%20%26amp%3B%20Disease%3C%5C%2Fi%3E%2C%20%3Ci%3E12%3C%5C%2Fi%3E%285%29%2C%201%26%23x2013%3B14.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41419-021-03763-z%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41419-021-03763-z%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D7753456%26amp%3Bitem_key%3DSJCWZSX9%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22RNA%20m%206%20A%20reader%20YTHDF2%20facilitates%20lung%20adenocarcinoma%20cell%20proliferation%20and%20metastasis%20by%20targeting%20the%20AXIN1%5C%2FWnt%5C%2F%5Cu03b2-catenin%20signaling%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yin%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hao%22%2C%22lastName%22%3A%22Sheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Feng%22%2C%22lastName%22%3A%22Ma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qiang%22%2C%22lastName%22%3A%22Wu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jianfang%22%2C%22lastName%22%3A%22Huang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qiang%22%2C%22lastName%22%3A%22Chen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lianghe%22%2C%22lastName%22%3A%22Sheng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xinghai%22%2C%22lastName%22%3A%22Zhu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiaoxi%22%2C%22lastName%22%3A%22Zhu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Meng%22%2C%22lastName%22%3A%22Xu%22%7D%5D%2C%22abstractNote%22%3A%22Lung%20adenocarcinoma%20%28LUAD%29%20remains%20a%20leading%20cause%20of%20cancer-related%20deaths%20worldwide.%20YTHDF2%20is%20a%20reader%20of%20N6-methyladenosine%20%28m6A%29%20on%20RNA%20and%20plays%20a%20critical%20role%20in%20the%20initiation%20and%20propagation%20of%20myeloid%20leukemia%3B%20however%2C%20whether%20YTHDF2%20controls%20the%20development%20of%20LUAD%20remains%20to%20be%20explored.%20Here%2C%20we%20found%20that%20YTHDF2%20was%20significantly%20upregulated%20in%20LUAD%20compared%20with%20paracancerous%20normal%20tissues%2C%20and%20YTHDF2%20knockdown%20drastically%20inhibited%2C%20while%20its%20overexpression%20promoted%2C%20cell%20growth%2C%20colony%20formation%20and%20migration%20of%20LUAD%20cells%20in%20vitro.%20In%20addition%2C%20YTHDF2%20knockdown%20significantly%20inhibited%20tumorigenesis%20in%20a%20murine%20tumor%20xenograft%20model.%20Through%20the%20integrative%20analysis%20of%20RNA-seq%2C%20m6A-seq%2C%20CLIP-seq%2C%20and%20RIP-seq%20datasets%2C%20we%20identified%20a%20set%20of%20potential%20direct%20targets%20of%20YTHDF2%20in%20LUAD%2C%20among%20which%20we%20confirmed%20AXIN1%2C%20which%20encodes%20a%20negative%20regulator%20of%20the%20Wnt%5C%2F%5Cu03b2-catenin%20signaling%2C%20as%20a%20direct%20target%20of%20YTHDF2.%20YTHDF2%20promoted%20AXIN1%20mRNA%20decay%20and%20subsequently%20activated%20the%20Wnt%5C%2F%5Cu03b2-catenin%20signaling.%20Knockout%20of%20AXIN1%20sufficiently%20rescued%20the%20inhibitory%20effect%20of%20YTHDF2%20depletion%20on%20lung%20cancer%20cell%20proliferation%2C%20colony-formation%2C%20and%20migration.%20These%20results%20revealed%20YTHDF2%20to%20be%20a%20contributor%20of%20LUAD%20development%20acting%20through%20the%20upregulation%20of%20the%20AXIN1%5C%2FWnt%5C%2F%5Cu03b2-catenin%20signaling%2C%20which%20can%20be%20a%20potential%20therapeutic%20target%20for%20LUAD.%22%2C%22date%22%3A%222021-05-13%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41419-021-03763-z%22%2C%22ISSN%22%3A%222041-4889%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41419-021-03763-z%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%2243ZBJFKZ%22%5D%2C%22dateModified%22%3A%222021-05-13T16%3A15%3A20Z%22%7D%7D%5D%7D
Li, Y., Sheng, H., Ma, F., Wu, Q., Huang, J., Chen, Q., Sheng, L., Zhu, X., Zhu, X., & Xu, M. (2021). RNA m 6 A reader YTHDF2 facilitates lung adenocarcinoma cell proliferation and metastasis by targeting the AXIN1/Wnt/β-catenin signaling. Cell Death & Disease, 12(5), 1–14. https://doi.org/10.1038/s41419-021-03763-z Cite
