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Pulmonary Cell NewsTo identify potent antiviral innate immune agonists, researchers screened a panel of 75 microbial ligands that activate diverse signaling pathways and identified cyclic dinucleotides, canonical STING agonists, as antiviral.
[Science Immunology]
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Li, M., Ferretti, M., Ying, B., Descamps, H., Lee, E., Dittmar, M., Lee, J. S., Whig, K., Kamalia, B., Dohnalová, L., Uhr, G., Zarkoob, H., Chen, Y.-C., Ramage, H., Ferrer, M., Lynch, K., Schultz, D. C., Thaiss, C. A., Diamond, M. S., & Cherry, S. (2021). Pharmacological activation of STING blocks SARS-CoV-2 infection. Science Immunology, 6(59). https://doi.org/10.1126/sciimmunol.abi9007 Cite
