LncRNA SNHG10 Promotes the Proliferation and Invasion of Osteosarcoma via Wnt/β-Catenin Signaling

In vitro experiments (including colony formation, CCK-8, wound healing and transwell assays) and in vivo experiments indicated that down-regulation of SNHG10 significantly suppressed the proliferation and invasion of osteosarcoma cells
[Molecular Therapy-Nucleic Acids]
Zhu, S., Liu, Y., Wang, X., Wang, J., & Xi, G. (2020). LncRNA SNHG10 promotes the proliferation and invasion of osteosarcoma via Wnt/β-catenin signaling. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.10.010 Cite
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EZH2 Regulates Expression of FOXC1 by Mediating H3K27me3 in Breast Cancers

Scientists demonstrated that the expression of FOXC1 was associated with resistance of doxorubicin treatment of breast cancer cells.
[Acta Pharmacologica Sinica]
Zheng, X., Li, W., Yi, J., Liu, J., Ren, L., Zhu, X., Liu, S., Wang, J., & Du, G. (2020). EZH2 regulates expression of FOXC1 by mediating H3K27me3 in breast cancers. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-00543-x Cite
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High-Fidelity Drug Induced Liver Injury Screen Using Human PSC-derived Organoids

Researchers established a human liver organoid (HLO) based screening model for analyzing DILI pathology at organoid resolution. HLO, generated from ten-different pluripotent stem cell lines, contained polarized immature hepatocytes with bile canaliculi-like architecture, establishing the unidirectional bile acid transport pathway.
[Gastroenterology]
Shinozawa, T., Kimura, M., Cai, Y., Saiki, N., Yoneyama, Y., Ouchi, R., Koike, H., Maezawa, M., Zhang, R.-R., Dunn, A., Ferguson, A., Togo, S., Lewis, K., Thompson, W., Asai, A., & Takebe, T. (2020). High-Fidelity Drug Induced Liver Injury Screen Using Human PSC-derived Organoids. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2020.10.002 Cite
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TIMP-2 Regulates Proliferation, Invasion and STAT3-Mediated Cancer Stem Cell-Dependent Chemoresistance in Ovarian Cancer Cells

FT282, JHOS2 and OVCAR4 cells were transiently transfected with either single or pooled TIMP-2 siRNAs. The expression of different genes after TIMP-2 knock down or in response to chemotherapy was determined at the mRNA level by quantitative real time PCR and at the protein level by immunofluorescence.
[BMC Cancer]
Escalona, R. M., Bilandzic, M., Western, P., Kadife, E., Kannourakis, G., Findlay, J. K., & Ahmed, N. (2020). TIMP-2 regulates proliferation, invasion and STAT3-mediated cancer stem cell-dependent chemoresistance in ovarian cancer cells. BMC Cancer, 20(1), 960. https://doi.org/10.1186/s12885-020-07274-6 Cite
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Transcriptome-Wide Analysis and Modelling of Prognostic Alternative Splicing Signatures in Invasive Breast Cancer: A Prospective Clinical Study

RNA sequencing of IBC samples from The Cancer Genome Atlas was acquired. Alternative splicingevents were screened by conducting univariate and multivariate Cox analysis and least absolute shrinkage and selection operator regression.
[Scientific Reports]
Wang, L., Wang, Y., Su, B., Yu, P., He, J., Meng, L., Xiao, Q., Sun, J., Zhou, K., Xue, Y., & Tan, J. (2020). Transcriptome-wide analysis and modelling of prognostic alternative splicing signatures in invasive breast cancer: a prospective clinical study. Scientific Reports, 10(1), 16504. https://doi.org/10.1038/s41598-020-73700-1 Cite
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Transient Activation of the Hedgehog-Gli Pathway Rescues Radiotherapy-Induced Dry Mouth via Recovering Salivary Gland Resident Macrophages

Researchers showed in mice that activation of canonical Gli-dependent Hedgehog signaling by Gli1 gene transfer was sufficient to recover salivary function impaired by irradiation.
[Cancer Research]
Zhao, Q., Zhang, L., Hai, B., Wang, J., Baetge, C. L., Deveau, M. A., Kapler, G. M., Feng, J. Q., & Liu, F. (2020). Transient activation of the Hedgehog-Gli pathway rescues radiotherapy-induced dry mouth via recovering salivary gland resident macrophages. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-0503 Cite
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hsa_circNFXL1_009 Modulates Apoptosis, Proliferation, Migration, and Potassium Channel Activation in Pulmonary Hypertension

The authors explored the circular RNA profile in pulmonary arterial hypertension patients caused by chronic obstructive pulmonary disease and the effects of hsa_circNFXL1_009 on abnormal proliferation, apoptosis, and migration of human pulmonary arterial smooth muscle cells driven by hypoxia.
[Molecular Therapy-Nucleic Acids]
Jin, X., Xu, Y., Guo, M., Sun, Y., Ding, J., Li, L., Zheng, X., Li, S., Yuan, D., & Li, S.-S. (2020). hsa_circNFXL1_009 modulates apoptosis, proliferation, migration, and potassium channel activation in pulmonary hypertension. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.09.029 Cite
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Peptidome Analysis of Umbilical Cord Mesenchymal Stem Cell (hUC-MSC) Conditioned Medium from Preterm and Term Infants

Investigators used tandem mass tag labeling technology followed by tandem mass spectrometry to compare the peptidomic profile of preterm and term umbilical cord MSC conditioned medium.
[Stem Cell Research & Therapy]
Wang, Y., Zhang, L., Wu, Y., Zhu, R., Wang, Y., Cao, Y., Long, W., Ji, C., Wang, H., & You, L. (2020). Peptidome analysis of umbilical cord mesenchymal stem cell (hUC-MSC) conditioned medium from preterm and term infants. Stem Cell Research & Therapy, 11(1), 414. https://doi.org/10.1186/s13287-020-01931-0 Cite
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Body Temperature-Dependent MicroRNA Expression Analysis in Rats: rno-miR-374-5p Regulates Apoptosis in Skeletal Muscle Cells via Mex3B under Hypothermia

To elucidate the molecular mechanism of homeostasis in hypothermia and identify novel molecular markers to inform the diagnosis of fatal hypothermia, scientists focused on microRNA expression in skeletal muscle, which plays a role in cold-induced thermogenesis in mammals.
[Scientific Reports]
Umehara, T., Kagawa, S., Tomida, A., Murase, T., Abe, Y., Shingu, K., & Ikematsu, K. (2020). Body temperature-dependent microRNA expression analysis in rats: rno-miR-374-5p regulates apoptosis in skeletal muscle cells via Mex3B under hypothermia. Scientific Reports, 10(1), 15432. https://doi.org/10.1038/s41598-020-71931-w Cite
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Long Non-Coding RNA SNHG3, Induced by IL-6/STAT3 Transactivation, Promotes Stem Cell-Like Properties of Gastric Cancer Cells by Regulating the miR-3619-5p/ARL2 Axis

Scientists clarified the potential involvement of long non-coding RNA SNGH3 in the acquisition of cisplatin resistance and stemness in gastric cancer.
[Cellular Oncology]
Sun, B., Han, Y., Cai, H., Huang, H., & Xuan, Y. (2020). Long non-coding RNA SNHG3, induced by IL-6/STAT3 transactivation, promotes stem cell-like properties of gastric cancer cells by regulating the miR-3619-5p/ARL2 axis. Cellular Oncology. https://doi.org/10.1007/s13402-020-00560-2 Cite
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EIF4A3-Induced Circular RNA ASAP1 (circASAP1) Promotes Tumorigenesis and Temozolomide Resistance of Glioblastoma via NRAS/MEK1/ERK1/2 Signaling

CircASAP1 expression was significantly up-regulated in recurrent glioblastoma (GBM) tissues and temozolomide-resistant cell lines. CircASAP1 overexpression enhanced GBM cell proliferation and temozolomide-resistance, which could reduced by circASAP1 knockdown.
[Neuro-Oncology]
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