regulatory T cells

[Advanced Science] Among various cell sources, FGL1/PD-L1 small extracellular vesicles (sEVs) derived from MSCs not only enriched FGL1/PD-L1 expression but also maintained the immunomodulatory properties of unmodified MSC sEVs.

[PLoS Neglected Tropical Diseases] Scientists investigated the expression of FOXP3+ Treg cells in leprosy skin lesions and to correlate their clinical forms, laboratory characteristics, and the immune reconstitution syndrome in HIV-leprosy co-infection.

[Nature Communications] Investigators showed that the 4-1BB CSD-associated tonic signal yielded a more dramatic effect in CAR-Tregs than in CAR- conventional T cells with respect to activation and proliferation.

[Cell Reports] Mice with an intestinal epithelial cells-intrinsic deletion of MHC class II were healthy but have fewer microbial-bound IgA, regulatory T cells, and immune repertoire selection.

[Journal of the American Heart Association] The percentage of Tregs in the spleen, blood, and brain was detected using flow cytometry, and the number of Tregs in the ischemic hemisphere was counted using transgenic mice with an enhanced green fluorescent protein‐tagged Foxp3.

[Cellular & Molecular Immunology] Both transplantation of wild-type bone marrow and adoptive transfer of wild-type Treg cells could prevent liver injury in AMPKα1-KO mice.