regulatory T cells

[Communications Biology] Scientists demonstrated that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha driven acquisition of CD73 expression.

[Nature Communications] Researchers demonstrated that single-cell sequencing of melanoma-infiltrating immune cells showed that adenylate cyclase inhibitor micelles reduced the number of anti-inflammatory myeloid cells and checkpoint receptor expression on T cells.

[Nature Communications] The authors showed that extracellular vesicles isolated from the synovial fluid of patients with juvenile idiopathic arthritis contribute to T cell suppression in a CD73-dependent manner.

[Journal of Cell Communication and Signaling] The authors explain the basic mechanisms for the interactions and communications between immunosuppressive, anti-tumoral, and cancer cells within the tumor microenvironment (TME), and discuss the modulating effects of metformin on various cells and secretions in the TME.

[Stem Cell Research & Therapy] The effect of MSCs on proliferation of anti-CD3/CD28-stimulated T CD4+ cells and generation of Tregs with or without pre-treatment with mitomycin C, IFN-γ and IL-1β was evaluated by flow cytometry.

[Journal of Reproduction and Development] Investigators determined the effect of intrauterine administration of mouse PBMCs prior to embryo implantation on endometrial receptivity and embryo implantation, and examined the underlying mechanism of Treg/Th17 cell balance following intrauterine administration of PBMCs.