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regulatory T cells

TGF-β-Induced CD4+ FoxP3+ Regulatory T Cell-Derived Extracellular Vesicles Modulate Notch1 Signaling through miR-449a and Prevent Collagen-Induced Arthritis in a Murine Model

[Cellular & Molecular Immunology] Considering that the stability and plasticity of nTregs remain major challenges in vivo, scientists established extracellular vesicles derived from in vitro TGF-β-induced Treg cells and assessed their functions in a murine model of autoimmune arthritis.

The Cross Talk between Gastric Cancer Stem Cells and the Immune Microenvironment: A Tumor-Promoting Factor

[Stem Cell Research & Therapy] Scientists provide an overview of bidirectional interactions between cancer stem cells and immune cells in gastric cancer, compiling relevant data about how CSCs can induce leukocyte reprogramming, resulting in pro-tumoral immune cells that orchestrate promotion of metastasis, chemoresistance, tumorigenicity, and even increase in number of cancer cells with stem properties.

Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance

[Frontiers in Immunology] Scientists described an anti-HLA-A2 CAR generated by grafting the complementarity-determining regions of a human monoclonal anti-HLA-A2 antibody into the framework regions of the Herceptin 4D5 single-chain variable fragment and fusing it with a CD28-ζ signaling domain.

High-Salt Diet Mediates Interplay between NK Cells and Gut Microbiota to Induce Potent Tumor Immunity

[Science Advances] The authors reported that high-salt diet induces natural killer cell–mediated tumor immunity by inhibiting PD-1 expression while enhancing IFNγ and serum hippurate.

scRNA-Seq of Human Vitiligo Reveals Complex Networks of Subclinical Immune Activation and a Role for CCR5 in Treg Function

[Science Translational Medicine] Scientists performed single-cell RNA sequencing on affected and unaffected skin from patients with vitiligo, as well as healthy controls, to define the role of each cell type in coordinating autoimmunity during disease progression.

PPM1D Is a Potential Prognostic Biomarker and Correlates with Immune Cell Infiltration in Hepatocellular Carcinoma

[Aging] Protein phosphatase magnesium-dependent 1 delta (PPM1D) mRNA expression was significantly higher in several human cancers, including hepatocellular carcinoma (HCC), than in the corresponding normal human tissues. The PPM1D mRNA high expression in HCC was significantly correlated with poor prognosis.

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