TGF-β-Induced CD4⁺ FoxP3⁺ Regulatory T Cell-Derived Extracellular Vesicles Modulate Notch1 Signaling through miR-449a and Prevent Collagen-Induced Arthritis in a Murine Model

Considering that the stability and plasticity of nTregs remain major challenges in vivo, scientists established extracellular vesicles derived from in vitro TGF-β-induced Treg cells and assessed their functions in a murine model of autoimmune arthritis.