reporter assay

[Environmental Toxicology] Dysregulated miRNAs have been promulgated as oncogenes or tumor-suppressive genes participating in the initiation and progression of colorectal cancer (CRC). Scientists reported that miR-346 was highly expressed in CRC patients.

[Cell Biology International] Researchers suggested that upregulation of miR-122 induced apoptosis, potentially via the repression of insulin-like growth factor 1 receptor (IGF1R) in human dermal papilla cells of androgenetic alopecia.

[Metabolic Brain Disease] Investigators explored the potential role and mechanism of circ_0057583 in brain microvascular endothelial cell injury. Human brain microvascular endothelial cells were exposed to different doses of lipopolysaccharide to induce cell damage.

[European Journal of Neurology] The authors screened the circular RNAs (circRNA) influencing matrix metalloproteinase-9 (MMP9) through the competing endogenous RNA network and evaluated the prognostic value of these circRNAs for acute ischemic stroke.

[Oncology Letters] The molecular mechanism underlying the role of FOXD3‑AS1 in cancer development has not yet been fully elucidated. Researchers focused on non‑small cell lung cancer in order to gain insight into how FOXD3‑AS1 drives cancer progression.

[Bioengineered] The effect of astragalus polysaccharide on dysfunctional insulin cells was investigated to clarify whether astragalus polysaccharide could be a novel drug for type 2 diabetes mellitus treatment.