rheumatoid arthritis

[Scientific Reports] Researchers investigated the ability of a recombinant BTN2A2-IgG2a Fc fusion protein to treat Collagen type II (CIA). They showed that administration of BTN2A2-Ig attenuatex established CIA, as compared with control Ig protein treatment.

[Nature Reviews Rheumatology] Scientists synthesize literature published in the past two years on the role of non-coding RNAs in osteoarthritis and rheumatoid arthritis with a focus on inflammation, cell death, cell proliferation and ECM dysregulation.

[Nature Reviews Gastroenterology & Hepatology] The authors consolidate knowledge on diet–microbiome interactions in local inflammation, gut microbiota imbalance and host immune dysregulation.

[Communications Biology] Investigators identified a TLR4+ follicular helper T cell-like population present in the blood and expanded in synovial fluid.

[Nature Communications] Scientists positionally identified a polymorphic estrogen receptor binding site that regulated Cd2 expression, leading to female-specific differences in T cell-dependent mouse models of autoimmunity.

[COVID-19 Immunity Task Force] More than 7 million Canadians suffer from immune-mediated inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, psoriasis, and related conditions. The COVID-19 Immunity Task Force and Vaccine Surveillance Reference Group will supporting a nationwide study that will assess COVID-19 vaccine effectiveness, safety and vaccine hesitancy in this potentially vulnerable group of people.