rheumatoid arthritis

[Cell Death & Disease] Rheumatoid arthritis synovial fluid increased endothelial progenitor cell homing and angiogenesis, which was blocked by the CXCL13 antibody.

[Immunologic Research] The authors explored the correlations between hyaluronic acid (HA) concentration versus mast cell proteases, or matrix metalloproteinase-2/9 and investigated the association of mast cell-specific proteases with disrupted synovial HA homeostasis in rheumatoid arthritis or collagen-induced arthritis rats.

[Science Advances] Researchers used CRISPR-Cas9 genome editing of iPSCs to create a synthetic gene circuit that sensed changing levels of endogenous inflammatory cytokines to trigger a proportional therapeutic response.

[Scientific Reports] Researchers investigated arthritis development in male DBA/1 mice which were injected with bovine collagen II and human fibrinogen on days 0 and 21, leading to stable and reproducible disease induction in 100% of immunized mice.

[Medexus Pharmaceuticals, Inc.] Medexus Pharmaceuticals, Inc. announced that is has completed enrollment in its Phase IV Clinical Trial of IXINITY®, targeting label expansion for pediatric hemophilia B patients.

[Stem Cell Research] Scientists generated an induced pluripotent stem cells (iPSC) line from bone marrow-MSCs employing a non-integrating episomal vector. The generated iPSCs expressed pluripotency markers, showed a normal karyotype, and exhibited the potential for in vitro differentiation into three germ layers.