Disrupted Homeostasis of Synovial Hyaluronic Acid and Its Associations with Synovial Mast Cell Proteases of Rheumatoid Arthritis Patients and Collagen-Induced Arthritis Rats

The authors explored the correlations between hyaluronic acid (HA) concentration versus mast cell proteases, or matrix metalloproteinase-2/9 and investigated the association of mast cell-specific proteases with disrupted synovial HA homeostasis in rheumatoid arthritis or collagen-induced arthritis rats.