SARS-CoV-2 Inhibits Induction of the MHC Class I Pathway by Targeting the STAT1-IRF1-NLRC5 Axis

Analysis of the gene expression profile from COVID-19 patients as well as SARS-CoV-2 infected epithelial cell lines revealed that the induction of the MHC class I pathway was inhibited by SARS-CoV-2 infection.
[Nature Communications]
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Mesenchymal Stromal Cell-Derived Extracellular Vesicles Reduce Lung Inflammation and Damage in Nonclinical Acute Lung Injury: Implications for COVID-19

Researchers identified a role for MSC-extracellular vesicles in immune modulation and cellular salvage in a model of SARS-CoV-2 induced acute lung injury using pulmonary epithelial cells and exposure to cytokines or the SARS-CoV-2 receptor binding domain.
[PLoS One]
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SARS-CoV-2 Infection and Replication in Human Gastric Organoids

Scientists generated gastric organoids from fetal, pediatric, and adult biopsies as in vitro models of SARS-CoV-2 infection.
[Nature Communications]
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Common Cardiac Medications Potently Inhibit ACE2 Binding to the SARS-CoV-2 Spike, and Block Virus Penetration and Infectivity in Human Lung Cells

Researchers found that ouabain, digitoxin and digoxin blocked penetration by SARS-CoV-2 Spike-pseudotyped virus into human lung cells, and infectivity by native SARS-CoV-2.
[Scientific Reports]
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SARS-CoV-2 B.1.1.7 (Alpha) and B.1.351 (Beta) Variants Induce Pathogenic Patterns in K18-hACE2 Transgenic Mice Distinct from Early Strains

Investigators demonstrated in K18-hACE2 transgenic mice that B.1.1.7 and B.1.351 were 100-fold more lethal than the original SARS-CoV-2 bearing 614D.
[Nature Communications]
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A Stem-Loop RNA RIG-I Agonist Protects against Acute and Chronic SARS-CoV-2 Infection in Mice

The authors assessed the antiviral capacity of a minimal RIG-I agonist, stem-loop RNA 1, in viral control, disease prevention, post-infection therapy, and cross-variant protection in mouse models of SARS-CoV-2 infection.
[Journal of Experimental Medicine]
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A Regulatory T Cell Signature Distinguishes the Immune Landscape of COVID-19 Patients from Those with Other Respiratory Infections

Scientists compared the immune signature from hospitalized SARS-CoV-2–infected patients to patients hospitalized prepandemic with influenza or respiratory syncytial virus.
[Science Advances]
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Direct SARS-CoV-2 Infection of the Human Inner Ear May Underlie COVID-19-Associated Audiovestibular Dysfunction

The authors reported a series of ten COVID-19 patients with audiovestibular symptoms such as hearing loss, vestibular dysfunction and tinnitus.
[Communications Medicine]
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Molecular Basis of Immune Evasion by the Delta and Kappa SARS-CoV-2 Variants

The authors showed that Kappa and Delta variants dampen the in vitro potency of vaccine-elicited serum neutralizing antibodies and provide a structural framework for describing their immune evasion.
[Science]
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Enhanced Protective Immunity against SARS-CoV-2 Elicited by a VSV Vector Expressing a Chimeric Spike Protein

Using wild-type and human ACE2 knock-in mouse models, investigators found a single dose of rVSV-SARS-CoV could elicit strong humoral immune response via both intranasal and intramuscular routes.
[Signal Transduction and Targeted Therapy]
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Sialic Acid-Containing Glycolipids Mediate Binding and Viral Entry of SARS-CoV-2

Researchers revealed that the receptor-binding domain of the spike protein on SARS-CoV-2 recognized oligosaccharides containing sialic acid, with preference for monosialylated gangliosides.
[Nature Chemical Biology]
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