single-cell RNA sequencing

[Nature Communications] Researchers performed single-cell RNA sequencing of 268,471 cells collected from 25 patients in four histologic stages of lung adenocarcinoma and compared them to normal cell types.

[Stem Cell Research & Therapy] The authors showed that donor differences in human MSC (hMSC) transcriptome were minor relative to the intrinsic differences in tissue-of-origin. hMSCs with different transcriptomic profiles showed potential differences in functional characteristics.

[Heliyon] Scientists reported a comprehensive pattern of Hopx expression in multiple types of immune cells under steady state conditions.

[Journal of Molecular and Cellular Cardiology] By administration of new techniques, including genetic cell lineage tracing and single cell RNA sequencing, more solid data were obtained that support the concept of stem/progenitor cells for regenerating damaged endothelium.

[Science Advances] Scientists demonstrated that Lyve-1+ tumor-associated macrophages supported tumor growth and identified a pivotal role for these cells in maintaining a population of perivascular mesenchymal cells that expressed α-smooth muscle actin and phenotypically resembled pericytes.

[Cell Death Discovery] Researchers formulated a comprehensive single-cell transcriptome atlas and contributed into novel insight of intratumor heterogeneity and molecular mechanism in metastatic pancreatic ductal adenocarcinoma.