survivin

[Cytokine] SH3PXD2A-AS1 silence was found to suppress HaCaT cell proliferation and promote HaCaT cell apoptosis significantly. Meanwhile, SH3PXD2A-AS1 silence significantly increased cleaved-caspase-3 protein levels and inhibited S100A7, TNF-α, IL-6, p-STAT3, STAT3, CyclinD1, and survivin protein levels.

[Clinical Cancer Research] Scientists investigated the significance of this mode of immune-escape on T cells engineered to express chimeric antigen receptors (CAR-T) cells.

[Journal of Pharmacy and Pharmacology] Lupeol could also inhibit proliferation and induce apoptosis of retinoblastoma cells, with increased Bax level and decreased Ki67, survivin and Bcl-2 levels.

[Cancer Discovery] CRISPR/Cas9-mediated ARID1A knockout in primary TP53-/- human gastric organoids induced morphologic dysplasia, tumorigenicity and mucinous differentiation.

[PLoS One] Human CD24-/CD44+ breast cancer stem cells (BCSCs) were treated with andrographolide in vitro for 24 hours. The cytotoxic effect of andrographolide on BCSCs was compared to that on human mesenchymal stem cells.

[British Journal of Cancer] Researchers showed that CDK9 induced non-small-cell lung cancer cell proliferation and that this effect was associated with STAT3 activation, specifically an increase in STAT3 phosphorylation and transcription factor activity.