temozolomide

[Cell Death & Disease] The role of hsa_circ_0110757 in temozolomide (TMZ)-resistant glioma was evaluated both in vitro and in vivo. It was found that hsa_circ_0110757 and ITGA1 were more highly expressed in TMZ-resistant glioma than in TMZ-sensitive glioma.

[Autophagy] Researchers investigated the molecular mechanisms underlying the antitumor effect of cannabidiol in preclinical models of human glioma.

[JNCI-Journal of the National Cancer institute] Treatment of glioma cells with the dopamine receptor antagonist quetiapine reduced glioma cell self-renewal in vitro and combined treatment of mice with quetiapine and radiation prolonged the survival of glioma-bearing mice.

[Science Advances] Scientists showed that elevation of CXCL1 or CXCL2 facilitated myeloid cell migration and simultaneously disrupted CD8+ T cell accumulation at tumor sites, causing accelerated tumor progression.

[Scientific Reports] Scientists analyzed Toll-like receptor 4 (TLR4) expression in different grades of astrocytoma, and observed increased expression in tumors, mainly in glioblastoma, compared to non-neoplastic brain tissue.

[Scientific Reports] The authors studied the anti-cancer effect of deer antler velvet in glioblastoma cell lines in comparison with temozolomide, a chemotherapeutic drug used to treat high-grade brain tumors.