TGFβ

[Stem Cells] Scientists exposed healthy bone marrow-derived CD34+ hematopoietic stem and progenitor cells (HSPC) to cell-free supernatants derived from acute myeloid leukemia (AML) cell lines to examine proliferation, cell cycling, colony formation, and differentiation of healthy CD34+ HSPC.

[Journal of Experimental Medicine] Investigators demonstrated that platelets were recruited into the lung together with neutrophils during the onset of inflammation and alongside Treg cells during the resolution phase.

[Nature Communications] The authors showed that Nur77 enhanced TGFβ/Smad3-induced ID1 mRNA expression through hindering Smurf2-mediated Smad3 mono-ubiquitylation, resulting in ID1 upregulation.

[iScience] Researchers found that endothelial SIRT3 regulated metabolic reprogramming and fibrogenesis in the kidneys of diabetic mice.

[Nature Communications] Using three different murine transgenic models, scientists provide counterintuitive evidence that the Alzheimer’s disease progression required B cells.

[Diabetologia] The effects of fetuin-A were assessed during in vitro maturation of porcine neonatal islet cell clusters and in adult human islets. Expression alterations were examined via microarray, RNA sequencing and reverse transcription quantitative real-time PCR, proteins were analyzed by western blotting and immunostaining, and insulin secretion was quantified in static incubations.