Acute Myeloid Leukemia-Induced Functional Inhibition of Healthy CD34⁺ Hematopoietic Stem and Progenitor Cells

Scientists exposed healthy bone marrow-derived CD34⁺ hematopoietic stem and progenitor cells (HSPC) to cell-free supernatants derived from acute myeloid leukemia (AML) cell lines to examine proliferation, cell cycling, colony formation, and differentiation of healthy CD34⁺ HSPC.