TGFβ

[Aging] The authors investigated the mechanism underlying the protective effects of galangin against H2O2/UVB-induced damage using in vitro and in vivo models of photodamage.

[Nature Communications] Researchers indicated that KLF4 played opposing roles in platelet-derived growth factor receptor-β+ cells and α-smooth muscle actin+ cells and highlighted the importance of further studies of interactions between distinct mesenchymal cell types.

[Oncogene] It was widely assumed that SMAD4-mutant (SMAD4mut) cancer cells were unable to undergo epithelial-mesenchymal transition (EMT). Researchers scrutinized this notion and probed for potential SMAD4-independent EMT execution using SMAD4mut colorectal cancer cell lines.

[Oncogene] The authors showed that TMEM201, as a positive modulator, was both necessary and sufficient to regulate the migration and invasion of breast cancer cells in vitro and in vivo.

[Stem Cell Reports] Through immunohistochemistry and inducible gene deletion, researchers found that the recruitment of stem/progenitor cells into degenerative mutant tendons originated from a Sox9-expressing lineage and their recruitment was dependent on cell autonomous TGFβ signaling.

[Scientific Reports] Immunocytochemical analysis confirmed SULF1/SULF2 expression in endothelial cell lining of blood vessels and in developing cardiomyocytes, but not in the adult cardiomyocytes despite persisting at reduced levels in the adult endothelial cells.