SMAD4 Mutations Do Not Preclude Epithelial–Mesenchymal Transition in Colorectal Cancer

It was widely assumed that SMAD4-mutant (SMAD4^mut) cancer cells were unable to undergo epithelial-mesenchymal transition (EMT). Researchers scrutinized this notion and probed for potential SMAD4-independent EMT execution using SMAD4^mut colorectal cancer cell lines.