TNF-α

[Cell Death Discovery] The authors investigated the mechanism of exosomes from adipose-derived MSCs in sepsis-induced acute lung injury.

[PLoS Pathogens] Investigators assessed the influence of COVID-19 plasma hypercytokinemia on the functional responses of myeloid immune cells upon bacterial challenges from acute-phase COVID-19 patients and their corresponding recovery (rec)-phase.

[Journal of Experimental Medicine] The authors found that the STING S365A mutation, which abrogated IRF3 binding and type I interferon induction, rescued the embryonic lethality of DNase II−/− mice.

[Bone] In type 2 diabetes mellitus mice scientists inhibited systemic activation of T cells with a fusion protein between the extracellular domain of Cytotoxic T-Lymphocyte Antigen 4 and the Fc domain of human immunoglobulin G.

[Bioengineered] The underlying molecular mechanisms of PSP in improving insulin resistance (IR) in skeletal muscle remain unclear. PA induced an IR model in L6 myotubes. After treatment, cell proliferation was measured using the CCK8.

[physiological reports] Investigators tested the hypothesis that the cystic fibrosis transmembrane conductance regulator regulated endothelial actin cytoskeleton dynamics and cellular alignment in response to flow.