tumor associated macrophages

[Cell Reports] The authors revealed that deoxythymidylate kinase (DTYMK) levels significantly increased and correlated with poor prognosis in hepatocellular carcinoma (HCC).

[Oncogene] Researchers showed that the activation of the RON receptor tyrosine kinase signaling pathway specifically in macrophages supports breast cancer growth and metastasis.

[ACS Nano] The authors developed a precise M2 TAM-targeted delivery system using “eat-me” and “don’t-eat-me” signals.

[Journal of Cellular Biochemistry] Researchers examined the role of Bcl2-associated athanogene (BAG3) to activate human fibroblasts in releasing cytokines capable of supporting tumor progression.

[Cell Death Discovery] The authors demonstrated that MMP1 derived from tumor-associated macrophages markedly facilitated colon cancer cell proliferation via accelerating cell cycle transition from G0/G1 to S and G2/M phase.

[Nature Cancer] By screening a collection of small-molecule compounds, investigators found that inhibiting β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) with MK-8931 potently reprogrammed tumor-promoting macrophages into tumor-suppressive macrophages and promotes macrophage phagocytosis of glioma cells.