tumor associated macrophages

[Journal of Nanobiotechnology] Scientists developed a novel nanocomposite, polyethyleneimine-modified dendritic mesoporous silica nanoparticles loaded with microRNA-125a to synergistically enhance immune response and immunosuppression reversion, ultimately generating a tumoricidal environment.

[Signal Transduction and Targeted Therapy] Macrophages are among the most abundant immune cells in colorectal cancer. Differentially expressed genes were found to be enriched in unfolded protein response/endoplasmic reticulum stress response processes, and XBP1 splicing/activation was specifically observed in tumor-associated macrophages.

[Journal of Cell Communication and Signaling] The authors explain the basic mechanisms for the interactions and communications between immunosuppressive, anti-tumoral, and cancer cells within the tumor microenvironment (TME), and discuss the modulating effects of metformin on various cells and secretions in the TME.

[Seminars in Cancer Biology] The authors discuss the interplay between H. pylori and tumor-supportive cells, including mesenchymal stem cells, cancer-associated fibroblasts, tumor-associated macrophages, and myeloid derived-suppressor cells in gastric cancer.

[European Journal of Cancer] Murine breast cancer cells were grown in both immune-competent and -deficient BALB/c mice, and tumors were irradiated by three fractions of 24 Gy. A PD-1 blockade and a phosphoinositide 3-kinase (PI3K)γδ inhibitor were then administered every other day for two weeks.

[Molecular Medicine] In view of the recent success in oncology obtained by stimulating the immune system, scientists discuss some macrophage-targeted therapeutic strategies that may also affect the CSCs and interrupt their malevolent alliance.