tumor-infiltrating lymphocytes

[Journal of Clinical Investigation] The authors reported that targeting of HIF-1α suppressed PD-L1 expression on tumor cells and tumor-infiltrated myeloid cells, but unexpectedly induced PD-L1 in normal tissues by an IFNγ–dependent mechanism.

[Oncogene] Scientists demonstrate that activated T cells armed with anti-CD3 x anti-EGFR bispecific antibody increases tumor infiltrating lymphocytes and mediate anti-tumor cytotoxicity while decreasing tumor cell viability.

[Biophysical Journal] The authors demonstrated that T cells exposed to high-e dose-dependently accumulated [K+]e intracellularly.

[Carcinogenesis] Scientists indicated that intermittently blocking TCR signal by tacrolimus could promote anti-tumor immunity and inhibit the tumor growth in melanoma-bearing mice, inhibiting the transcription of several exhaustion-related genes, such as Nr4a1 and Ctla4.

[Cell Reports] Using single-cell sequencing, scientists showed that tumor-induced lymphocytes include skewed T cell clonotypes, which were characterized by exhaustion or nonexhaustion signatures.

[Science] By mapping 55 neoantigen-specific TCR clonotypes from 10 metastatic human tumors to their single-cell transcriptomes, scientists identified signatures of CD8+ and CD4+ neoantigen-reactive tumor-infiltrating lymphocytes.