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[Proceedings of the National Academy of Sciences of the United States of America] we demonstrated that Patch-seq technology can be applied both to better understand molecular mechanisms underlying a complex neurological disease at the single-cell level and to provide a platform for screening for therapeutics for the disease.

[Cancer Cell] Using isogenic Ewing cells, researchers showed STAG2 loss of function profoundly changed the transcriptome but it did not significantly impact EWSR1-FLI1, CTCF/cohesin, or acetylated H3K27 DNA binding patterns.

Researchers report that CRISPR–RfxCas13d could effectively discriminate circRNAs from mRNAs by using guide RNAs targeting sequences spanning back-splicing junction sites featured in RNA circles.

Scientists conducted a bioinformatics analysis of COVID-19 comorbidity-associated gene sets, identifying genes and pathways shared among the comorbidities, and evaluated current knowledge about these genes and pathways as related to current information about SARS-CoV-2 infection.