STAG2 Mutations Alter CTCF-Anchored Loop Extrusion, Reduce Cis-Regulatory Interactions and EWSR1-FLI1 Activity in Ewing Sarcoma

By
Justin.choi
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0
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Using isogenic Ewing cells, researchers showed STAG2 loss of function profoundly changed the transcriptome but it did not significantly impact EWSR1-FLI1, CTCF/cohesin, or acetylated H3K27 DNA binding patterns.
[Cancer Cell]
Surdez, D., Zaidi, S., Grossetête, S., Laud-Duval, K., Ferre, A. S., Mous, L., Vourc’h, T., Tirode, F., Pierron, G., Raynal, V., Baulande, S., Brunet, E., Hill, V., & Delattre, O. (2021). STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2021.04.001 Cite
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