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A Non-Invasive Mouse Model That Recapitulates Disuse-Induced Muscle Atrophy in Immobilized Patients

[Scientific Reports] Researchers performed the next-generation sequencing analysis of gastrocnemius muscles from immobilized versus non-mobilized legs.

Zonisamide Attenuates Pressure Overload-Induced Myocardial Hypertrophy in Mice through Proteasome Inhibition

[Acta Pharmacologica Sinica] The authors investigated whether zonisamide prevented pressure overload-caused myocardial hypertrophy through suppressing proteasome.

Chemokine CCL2 Promotes Cardiac Regeneration and Repair in Myocardial Infarction Mice via Activation of the JNK/STAT3 Axis

[Acta Pharmacologica Sinica] Scientists investigated the role of CCL2 in cardiac regeneration and the underlying mechanisms. Myocardial infarction was induced in adult mice by permanent ligation of the left anterior descending artery.

Macromolecular Complex Including MLL3, Carabin, and Calcineurin Regulates Cardiac Remodeling

[Circulation Research] Protein interaction was determined by immunoprecipitation assay in primary cardiomyocytes and mouse cardiac samples subjected or not to transverse aortic constriction for one week.

Electronic Cigarette Exposure Disrupts Airway Epithelial Barrier Function and Exacerbates Viral Infection

[American Journal Of Physiology-Lung Cellular And Molecular Physiology] Using confluent human bronchial epithelial cells and well-differentiated normal human bronchial epithelial cells, scientists found that exposure to extract and aerosol e-cig nicotine caused a significant decrease in trans-epithelial electrical resistance and the structure of the apical junctional complexes even at non-cytotoxic concentrations.

RPI and Albany Medical College Researchers Awarded $3.3 Million To Improve Breast Cancer Treatment Using Artificial Intelligence

[Albany Medical College] Researchers from Rensselaer Polytechnic Institute (RPI) and Albany Medical College were awarded a $3.3 million grant over five years by the National Cancer Institute to use artificial intelligence to improve targeted drug therapy in HER2-positive breast cancer treatment.