we demonstrated that Patch-seq technology can be applied both to better understand molecular mechanisms underlying a complex neurological disease at the single-cell level and to provide a platform for screening for therapeutics for the disease.
[Proceedings of the National Academy of Sciences of the United States of America]
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Paraskevopoulou, F., Parvizi, P., Senger, G., Tuncbag, N., Rosenmund, C., & Yildirim, F. (2021). Impaired inhibitory GABAergic synaptic transmission and transcription studied in single neurons by Patch-seq in Huntington’s disease. Proceedings of the National Academy of Sciences, 118(19). https://doi.org/10.1073/pnas.2020293118 Cite